Provider: Moravian Museum, Brno, Czech Republic

TY  - JOUR
JO  - Anthropologie (Brno)
TI  - Reciprocal chromosome translocations in 437 couples with reproductive disorders
AU  - Boroòová I
AU  - Bernasovský I
AU  - Bernasovská J
AU  - Behulová R
AU  - Petrejèíková E
AU  - Bôžiková A
AU  - Gabriková D
AU  - Maèeková S
AU  - Soták M
AU  - Sovièová A
AU  - Sikorová L
Y1  - 2010
VL  - 48
IS  - 2
PB  - Moravian Museum, Brno, Czech Republic
SN  - 0323-1119
SP  - 195
EP  - 197
KW  - Chromosome aberrations
KW  - Reciprocal translocations
KW  - Reproductive disorders
N2  - 
N2  - Chromosomal abnormalities are the major contributors to genetic causes of reproductive disorders. The aim of this study was to determine the occurence of reciprocal chromosome translocations in couples with reproductive disorder from the Prešov region (Slovakia) in 1998-2010. We analyzed the karyotypes of 437 couples with clinical diagnosis of reproductive disorder including infertility, recurrent fetal loss, congenital anomalies in the offsprings and sterility. The karyotypes were determined using cytogenetic banding techniques (GTG-banded metaphases). Routine cytogenetic analyses involved a total of 48 aberrant karyotypes corresponding to an abnormality frequency of 5.5%. Reciprocal chromosome translocations were found in six couples (1.4%), four female (0.9%) and two male (0.5%) partners. The identification of chromosomal abnormalities as the etiology facilitated the counseling and appropriate management.
ER  -