Provider: Moravian Museum, Brno, Czech Republic

TY  - JOUR
JO  - Anthropologie (Brno)
TI  - Ethnic difference frequencies of THSD7A variant, but no association with obesity
AU  - Mačeková S
AU  - Mathia M
AU  - Varaliová Z
AU  - Bernasovská J
AU  - Boroňová Y
AU  -
Dojčaková D
AU  - Petrejčíková E
AU  - Galová J
AU  - Vašková H
Y1  - 2021
VL  - 59
IS  - 2
PB  - Moravian Museum, Brno, Czech Republic
SN  - 0323-1119
SP  - 205
EP  - 211
KW  - THSD7A gene – Obesity – Polymorphism – Association study – Angiogenesis
N2  - 
N2  - The THSD7A gene has recently been described as a "obesity gene". The product of this gene significantly
modulates angiogenesis, a process linked to adipogenesis, growth of adipose tissue and the development of an obese
phenotype. It can therefore be assumed that the role of this gene in obesity may be due to its angiogenic activity. The
aim of this study was to analyze allele and genotypic frequencies of rs1526538 polymorphism in THSD7A gene and
investigate its possible relationship with obesity indicators. The study included 407 individuals of Roma origin and
229 individuals of the majority population in eastern Slovakia. Anthropometric measurements of body height (cm),
body weight (kg), waist circumference (cm), and hip circumference (cm) were performed by standard methods to all
participants, and BMI, WHR and WHTR indexes were calculated. Buccal mucosa sample were obtained from all the
participants and DNA isolation was performed by the commercial kit. SNP genotyping was done using the TaqMan
SNP Genotyping Assays. The frequency of the risk allele A was 47.9% in the Roma population and 60.9% in the Slovak
majority, suggesting ethnic variability in the frequency of this polymorphism. No significant relationship of this
polymorphism with obesity was confirmed in association analysis. Our study provided the evidence for ethnic difference
frequency of rs1526538 in THSD7A gene, but did not confirm relationship between this polymorphism and obesity
traits. However, further studies are needed to confirm or reject the hypothesis that this genetic determinant of
angiogenesis is involved in the etiopathogenesis of obesity.
ER  -