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'Zemková D, Koloušková S, Bartošová J, Macek M, Vávrová V, 2003: Nutritional Status of Czech Patients with Cystic Fibrosis: Is It Influenced by Diabetes mellitus and Insulin Therapy?. Anthropologie (Brno) 41, 1-2: 119-122'. |
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| Abstract | | Cystic fibrosis (CF) is a life-shortening autosomal recessive disease. CF manifests with chronic obstructive lung disease, exocrine pancreatic insufficiency, elevated sweat chloride concentration and in males infertility due to obstructive azoospermia. Monitoring of the nutritional status is very important, because nutritional intervention may slow the decline in pulmonary function. Impaired glucose tolerance and diabetes mellitus are frequent complications. Within the framework of CFRD screening the authors examined oral glucose tolerance test in 144 CF patients older than 10 years. In positive cases insulinopenia was assessed by i.v.GTT as a sum of insulin response in 1. and 3. mins. < 1 percentile in healthy controls (48 mIU/L). Body composition was assessed by anthropological parameters (height, weight, mid-arm circumference-SDS, 4 skinfolds). Controls with normal glucose tolerance were sex / age matched to cases. Insulinopenia was found in 31/144 CF patients. Insulinopenic patients were treated immediately by small dosage of intermediate insulin. Abnormal glucose metabolism appears to have a negative impact upon nutrition of CF patients. Early detection of insulinopenia by i. v. GTT and its early treatment improves nutritional status, stabilizes pulmonary function and improves life expectancy. | | | | Keywords | | Nutritional status - Cystic fibrosis - Diabetes mellitus - CFRD - Impaired glucose tolerance | | |
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