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'Škarić-Jurić T, Celinšćak Z, Šetinc M, Bočkor L, Stojanović Marković A,
Zajc Petranović M, Peričić Salihović M, Deelen J, Janićijević B, Smolej Narančić N, 2023: SO DIFFERENT BUT EQUAL: 33 LONGEVITY
GENES' LOCI IN THE ROMA AND IN THE
GENERAL POPULATION OF CROATIA. Anthropologie (Brno) 61, 1: 1-28'. |
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| Abstract | | The age pyramid of Roma populations tips strongly towards the younger age groups and is characterized by
a low number of elderly individuals. There is a vast range of environmental factors that influence the age structure of Roma
populations. To explore whether a genetic risk for premature mortality also exists in this ethnic minority, 33 single nucleotide
polymorphisms (SNPs) in 23 putative longevity genes were investigated in 308 adult Roma living in Croatia, and in
Croatian population sample, composed of 314 "Old" (85–101 yrs.) and 97 "Young" (20–35 yrs.) subjects. The cumulative
effect of the investigated SNPs, which have previously been related to human longevity, was summarized within Genetic
Longevity Score (GLS). After Bonferroni correction the "Old" and "Young" Croatian age groups differ only in the allele
frequency in MRE11A locus (rs533984), while the Roma had significantly different allele frequencies from the surrounding
majority population in most of the investigated longevity genes loci (in 16 out of the 33 SNPs). However, the Roma's GLS
is equal to those in the "Young" and "Old" Croatian cohorts implying identical chances of surviving to the age of 85 among
Roma as to the majority Croatian population, when only genetics is taken into account. | | | | Keywords | | Longevity – Genetic score – Premature mortality – Minority health – Roma – Croatia | | | | DOI | | https://doi.org/10.26720/anthro.22.04.29.1 | | |
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