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'Ghosh K, CHATTERJEE D, BANDYOPADHYAY AR, 2024: Association of Digit Ratios (2D:4D) and Age at Menopause: Possibility of an Economizing Biomarker. Anthropologie (Brno) 62, 2: 151-155'. |
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| Abstract | | Menopause represents an important transition in female life history. There is considerable variation in the timing of menopause (or age at menopause). Both the genetic factors and environmental exposures (both intra and extra uterine environments) are thought to contribute to an early or later initiation of it. Measurement of “Digit Ratio” (2D:4D) could be used as a non-invasive biomarker of age at menopause as prenatal sex hormones controls the differentiation of digits. As the numbers of postmenopausal women are increasing day by day both globally and nationally therefore researches should focus on this age group of women because the vulnerability of getting multiple illnesses is higher among them but very few studies are there on the association of 2D:4D ratio and age at natural menopause and perhaps not undertaken from India. In this backdrop the present attempt is to understand the association of digit ratio (2D:4D) with age at natural menopause form Eastern India (Bengalee Hindu Population), West Bengal, India. The present study conducted on 187 apparently healthy ever married natural post-menopausal women without nullipara. Structured schedule was used to take socio demographic and reproductive data. Digit ratios has been measured using standard technique. No Bilateral Asymmetry for 2D:4D ratio was found. Significant (p<0.05) difference between low and high digit ratio (2D:4D) with age menopause classified according to the median (50th percentile), indicating association with early age at menopause (≤ 50th percentile) and low digit ratio (2D:4D). Hence the present study envisaged plausibility of digit ratio as an economizing biomarker of age at menopause ameliorate the reproductive health of women | | | | Keywords | | Digit Ratio (2D:4D) – Menopause – Intra Uterine Environment – Biomarker | | | | DOI | | https://doi.org/10.26720/anthro.24.04.03.1 | | |
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